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Journal articles
Synthesis and antimycobacterial evaluation of benzofurobenzopyran analogues.: Synthesis and antimycobacterial evaluation of benzofurobenzopyran analogues.
Abstract : We recently reported that 3,3-dimethyl-3H-benzofuro[3,2,f][1]-benzopyran and its hydrogenated analogue are selective in vitro inhibitors of mycobacterial growth. However, their lack of in vivo activity on a murine model of Mycobacterium tuberculosis infection due to their poor bioavailability led to a structure-activity relationship investigation. We wish to report here the preparation of some structural analogues along with their biological effect on the growth of Mycobacterium smegmatis, M. tuberculosis, as well as on VERO cells for the most active compound.
https://hal-pasteur.archives-ouvertes.fr/pasteur-00166360
Contributor : Yves Janin Connect in order to contact the contributor
Submitted on : Saturday, August 4, 2007 - 4:05:37 PM
Last modification on : Wednesday, December 15, 2021 - 9:58:20 AM
Contributor : Yves Janin Connect in order to contact the contributor
Submitted on : Saturday, August 4, 2007 - 4:05:37 PM
Last modification on : Wednesday, December 15, 2021 - 9:58:20 AM