Expression of the Bacillus subtilis dinR and recA genes after DNA damage and during competence. - Institut Pasteur Accéder directement au contenu
Article Dans Une Revue Journal of Bacteriology Année : 1992

Expression of the Bacillus subtilis dinR and recA genes after DNA damage and during competence.

Résumé

The Bacillus subtilis dinR gene product is homologous to the LexA protein of Escherichia coli and regulates the expression of dinR and dinC. Using transcriptional fusions in the dinR and the recA genes, we have investigated the epistatic relationship between these two genes during the SOS response induced either by DNA damage or by competence. The results show that after DNA damage, induction of the expression of both recA and dinR is dependent on the activity of the DinR and RecA proteins. A RecA-dependent activity on DinR is proposed as the initial event in the induction of the SOS network. In contrast, the competence-related induction of dinR and recA appears to involve two distinct mechanisms. While one mechanism corresponds to the classical regulation of the SOS response, the other appears to involve an activating factor. Moreover, this factor is active in cells in which competence is prevented by a mutation in the regulatory gene comA.

Domaines

Autre [q-bio.OT]

Dates et versions

pasteur-00166276 , version 1 (02-08-2007)

Identifiants

Citer

Agnès Raymond-Denise, Nancy Guillén. Expression of the Bacillus subtilis dinR and recA genes after DNA damage and during competence.. Journal of Bacteriology, 1992, 174 (10), pp.3171-6. ⟨10.1128/jb.174.10.3171-3176.1992⟩. ⟨pasteur-00166276⟩

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