2'-fluoro-2'-deoxycytidine inhibits Borna disease virus replication and spread.

Jeffrey J Bajramovic (1) , Romain Volmer (1) , Sylvie Syan (1) , Sylvie Pochet (2) , Daniel Gonzalez-Dunia (1, 3)

1 Virus Lents
2 Chimie Organique
3 CPTP - Centre de Physiopathologie Toulouse Purpan

Borna disease virus (BDV) causes neurological diseases in a variety of warm-blooded animal species, possibly including humans. To date, there is no effective treatment against BDV infection. Recently, we reported on the antiviral activity of 1-beta-D-arabinofuranosylcytosine (Ara-C). However, Ara-C's cytotoxic side effects are a major obstacle for its therapeutic use. Herein, we demonstrate that the nucleoside analog 2'-fluoro-2'-deoxycytidine (2'-FdC) exhibits potent antiviral activity against BDV. Importantly, 2'-FdC-associated cytotoxicity is negligible, indicating 2'-FdC as an excellent candidate for the development of antiviral therapy against BDV.

Domains: Other [q-bio.OT]

Jeffrey J Bajramovic, Romain Volmer, Sylvie Syan, Sylvie Pochet, Daniel Gonzalez-Dunia. 2'-fluoro-2'-deoxycytidine inhibits Borna disease virus replication and spread.. Antimicrobial Agents and Chemotherapy, 2004, 48 (4), pp.1422-5. ⟨10.1128/AAC.48.4.1422-1425.2004⟩. ⟨pasteur-00166243⟩