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2'-fluoro-2'-deoxycytidine inhibits Borna disease virus replication and spread.

Abstract : Borna disease virus (BDV) causes neurological diseases in a variety of warm-blooded animal species, possibly including humans. To date, there is no effective treatment against BDV infection. Recently, we reported on the antiviral activity of 1-beta-D-arabinofuranosylcytosine (Ara-C). However, Ara-C's cytotoxic side effects are a major obstacle for its therapeutic use. Herein, we demonstrate that the nucleoside analog 2'-fluoro-2'-deoxycytidine (2'-FdC) exhibits potent antiviral activity against BDV. Importantly, 2'-FdC-associated cytotoxicity is negligible, indicating 2'-FdC as an excellent candidate for the development of antiviral therapy against BDV.
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Submitted on : Thursday, August 2, 2007 - 12:31:25 PM
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Jeffrey J Bajramovic, Romain Volmer, Sylvie Syan, Sylvie Pochet, Daniel Gonzalez-Dunia. 2'-fluoro-2'-deoxycytidine inhibits Borna disease virus replication and spread.. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2004, 48 (4), pp.1422-5. ⟨10.1128/AAC.48.4.1422-1425.2004⟩. ⟨pasteur-00166243⟩



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