Synthesis and incorporation into DNA fragments of the artificial nucleobase, 2-amino-8-oxopurine. - Archive ouverte HAL Access content directly
Journal Articles Bioorganic and Medicinal Chemistry Letters Year : 2005

Synthesis and incorporation into DNA fragments of the artificial nucleobase, 2-amino-8-oxopurine.

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Abstract

The nucleoside 2-amino-9-(2-deoxy-beta-d-ribofuranosyl)-7,8-dihydro-8-oxo-purine (dJ) was obtained in eight steps from 2'-deoxyguanosine. The appropriate protected phosphoramidite was synthesized and incorporated into DNA oligonucleotides. The thermal stability of heteroduplexes containing 2-amino-8-oxopurine (J) was investigated by UV-thermal denaturation experiments. The results obtained can be interpreted by the base pairing schemes involving the two edges of dJ depending on the anti and syn orientations.

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pasteur-00166211 , version 1 (01-08-2007)

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Claudio Cadena-Amaro, Muriel Delepierre, Sylvie Pochet. Synthesis and incorporation into DNA fragments of the artificial nucleobase, 2-amino-8-oxopurine.. Bioorganic and Medicinal Chemistry Letters, 2005, 15 (4), pp.1069-73. ⟨10.1016/j.bmcl.2004.12.021⟩. ⟨pasteur-00166211⟩

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