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Synthesis and incorporation into DNA fragments of the artificial nucleobase, 2-amino-8-oxopurine.

Abstract : The nucleoside 2-amino-9-(2-deoxy-beta-d-ribofuranosyl)-7,8-dihydro-8-oxo-purine (dJ) was obtained in eight steps from 2'-deoxyguanosine. The appropriate protected phosphoramidite was synthesized and incorporated into DNA oligonucleotides. The thermal stability of heteroduplexes containing 2-amino-8-oxopurine (J) was investigated by UV-thermal denaturation experiments. The results obtained can be interpreted by the base pairing schemes involving the two edges of dJ depending on the anti and syn orientations.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-00166211
Contributor : Sylvie Pochet <>
Submitted on : Wednesday, August 1, 2007 - 7:09:55 PM
Last modification on : Monday, January 13, 2020 - 5:08:05 PM

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Claudio Cadena-Amaro, Muriel Delepierre, Sylvie Pochet. Synthesis and incorporation into DNA fragments of the artificial nucleobase, 2-amino-8-oxopurine.. Bioorganic and Medicinal Chemistry Letters, Elsevier, 2005, 15 (4), pp.1069-73. ⟨10.1016/j.bmcl.2004.12.021⟩. ⟨pasteur-00166211⟩

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