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Nucleoside analogues as inhibitors of thymidylate kinases: possible therapeutic applications.

Sylvie Pochet 1 Laurence Dugué 1 Dominique Douguet 2 Gilles Labesse 2 Hélène Munier-Lehmann 3
1 Chimie Organique
2 CBS - Centre de Biochimie Structurale [Montpellier]
3 CSM - Chimie Structurale des Macromolécules
Abstract : Membrane‐permeable nonphosphorylated thymidine analogues (see structure) are active as competitive inhibitors of M. tuberculosis thymidylate kinase (TMPK) as well as of other bacterial TMPKs. A modeling and docking study was used to rationalize the experimental data.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-00166196
Contributor : Sylvie Pochet <>
Submitted on : Wednesday, August 1, 2007 - 6:27:32 PM
Last modification on : Thursday, September 16, 2021 - 9:12:02 AM

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PASTEUR | CNRS | BS | UNIV-MONTPELLIER

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Sylvie Pochet, Laurence Dugué, Dominique Douguet, Gilles Labesse, Hélène Munier-Lehmann. Nucleoside analogues as inhibitors of thymidylate kinases: possible therapeutic applications.. ChemBioChem, Wiley-VCH Verlag, 2002, 3 (1), pp.108-10. ⟨10.1002/1439-7633(20020104)3:1<108::AID-CBIC108>3.0.CO;2-B⟩. ⟨pasteur-00166196⟩

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