Nucleoside analogues as inhibitors of thymidylate kinases: possible therapeutic applications.

Sylvie Pochet (1) , Laurence Dugué (1) , Dominique Douguet (2) , Gilles Labesse (2) , Hélène Munier-Lehmann (3)

1 Chimie Organique
2 CBS - Centre de Biochimie Structurale [Montpellier]
3 CSM - Chimie Structurale des Macromolécules

Membrane‐permeable nonphosphorylated thymidine analogues (see structure) are active as competitive inhibitors of M. tuberculosis thymidylate kinase (TMPK) as well as of other bacterial TMPKs. A modeling and docking study was used to rationalize the experimental data.

Domains: Life Sciences [q-bio]

Sylvie Pochet, Laurence Dugué, Dominique Douguet, Gilles Labesse, Hélène Munier-Lehmann. Nucleoside analogues as inhibitors of thymidylate kinases: possible therapeutic applications.. ChemBioChem, 2002, 3 (1), pp.108-10. ⟨10.1002/1439-7633(20020104)3:1<108::AID-CBIC108>3.0.CO;2-B⟩. ⟨pasteur-00166196⟩