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NF-kappaB regulates spatial memory formation and synaptic plasticity through protein kinase A/CREB signaling.

Abstract : Synaptic activity-dependent de novo gene transcription is crucial for long-lasting neuronal plasticity and long-term memory. In a forebrain neuronal conditional NF-kappaB-deficient mouse model, we demonstrate here that the transcription factor NF-kappaB regulates spatial memory formation, synaptic transmission, and plasticity. Gene profiling experiments and analysis of regulatory regions identified the alpha catalytic subunit of protein kinase A (PKA), an essential memory regulator, as a new NF-kappaB target gene. Consequently, NF-kappaB inhibition led to a decrease in forskolin-induced CREB phosphorylation. Collectively, these results disclose a novel hierarchical transcriptional network involving NF-kappaB, PKA, and CREB that leads to concerted nuclear transduction of synaptic signals in neurons, accounting for the critical function of NF-kappaB in learning and memory.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-00163004
Contributor : Marie-Dominique Aytac <>
Submitted on : Monday, July 16, 2007 - 3:44:42 PM
Last modification on : Monday, January 13, 2020 - 5:08:09 PM

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Barbara Kaltschmidt, Delphine Ndiaye, Martin Korte, Stéphanie Pothion, Laurence Arbibe, et al.. NF-kappaB regulates spatial memory formation and synaptic plasticity through protein kinase A/CREB signaling.. Molecular and Cellular Biology, American Society for Microbiology, 2007, 26 (8), pp.2936-46. ⟨10.1128/MCB.26.8.2936-2946.2006⟩. ⟨pasteur-00163004⟩

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