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Deciphering the pathway from the TCR to NF-kappaB.

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Abstract

A major regulator of lymphocyte survival and activation is the transcription factor nuclear factor-kappaB (NF-kappaB). Controlled activation of NF-kappaB is essential for the immune and inflammatory response as well as for cell proliferation and protection against apoptosis. The NEMO/IkappaB kinase (IKK) complex is the central integrator of most stimuli leading to NF-kappaB activation, but a detailed knowledge of the upstream events is available only for a limited number of stimuli. In particular, although most players have probably been identified, relatively little is known about the detailed molecular mechanisms involved in the cascade leading to NF-kappaB activation following engagement of the T-cell receptor by a foreign antigen. In this review, we discuss recent insights into this specific signal transduction cascade, and the way it is controlled both spatially and temporally.

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pasteur-00162992 , version 1 (16-07-2007)

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R. Weil, A. Israël. Deciphering the pathway from the TCR to NF-kappaB.. Cell Death and Differentiation, 2007, 13 (5), pp.826-33. ⟨10.1038/sj.cdd.4401856⟩. ⟨pasteur-00162992⟩

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