NF-kappaB activation: Nondegradative ubiquitination implicates NEMO.

Alain Israël (1)

1 SMAC - Signalisation Moléculaire et Activation Cellulaire

Non-degradative ubiquitination events have been recently demonstrated to have an important role in activating the IkappaB kinase (IKK) complex, the central component of the nuclear factor (NF)-kappaB signaling cascade. Two new papers demonstrate that NF-kappaB essential modulator (NEMO)-IKKgamma, the structural and regulatory component of the IKK complex, specifically recognizes Lys63 polyubiquitin chains attached to the receptor-interacting protein (RIP)1 kinase following tumor necrosis factor treatment, and that this recognition is a requirement for IKK activation.

Domains: Biochemistry, Molecular Biology

Alain Israël. NF-kappaB activation: Nondegradative ubiquitination implicates NEMO.. Trends in Immunology, 2007, 27 (9), pp.395-7. ⟨10.1016/j.it.2006.07.003⟩. ⟨pasteur-00162860⟩