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NF-kappaB activation: Nondegradative ubiquitination implicates NEMO.

Abstract : Non-degradative ubiquitination events have been recently demonstrated to have an important role in activating the IkappaB kinase (IKK) complex, the central component of the nuclear factor (NF)-kappaB signaling cascade. Two new papers demonstrate that NF-kappaB essential modulator (NEMO)-IKKgamma, the structural and regulatory component of the IKK complex, specifically recognizes Lys63 polyubiquitin chains attached to the receptor-interacting protein (RIP)1 kinase following tumor necrosis factor treatment, and that this recognition is a requirement for IKK activation.
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Contributor : Marie-Dominique Aytac <>
Submitted on : Monday, July 16, 2007 - 12:02:29 PM
Last modification on : Monday, January 13, 2020 - 5:08:09 PM




Alain Israël. NF-kappaB activation: Nondegradative ubiquitination implicates NEMO.. Trends in Immunology, Elsevier, 2007, 27 (9), pp.395-7. ⟨10.1016/⟩. ⟨pasteur-00162860⟩



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