G. Werlen, B. Hausmann, D. Naeher, and E. Palmer, Signaling Life and Death in the Thymus: Timing Is Everything, Science, vol.299, issue.5614, pp.1859-1863, 2003.
DOI : 10.1126/science.1067833

D. Leitenberg and K. Bottomly, Regulation of naive T cell differentiation by varying the potency of TCR signal transduction, Seminars in Immunology, vol.11, issue.4, pp.283-292, 1999.
DOI : 10.1006/smim.1999.0184

B. Seddon and R. Zamoyska, Regulation of peripheral T-cell homeostasis by receptor signalling, Current Opinion in Immunology, vol.15, issue.3, pp.321-324, 2003.
DOI : 10.1016/S0952-7915(03)00049-9

M. E. Marquez, W. Ellmeier, V. Sanchez-guajardo, A. A. Freitas, O. Acuto et al., CD8 T Cell Sensory Adaptation Dependent on TCR Avidity for Self-Antigens, The Journal of Immunology, vol.175, issue.11, pp.7388-7397, 2005.
DOI : 10.4049/jimmunol.175.11.7388
URL : https://hal.archives-ouvertes.fr/hal-00138110

L. Duan, A. L. Reddi, A. Ghosh, M. Dimri, and H. Band, The Cbl Family and Other Ubiquitin Ligases, Immunity, vol.21, issue.1, pp.7-17, 2004.
DOI : 10.1016/j.immuni.2004.06.012

P. S. Ohashi, T-cell signalling and autoimmunity: molecular mechanisms of disease, Nat. Rev. Immunol, vol.2, pp.427-438, 2002.

M. S. Jordan, A. L. Singer, and G. A. Koretzky, Adaptors as central mediators of signal transduction in immune cells, Nature Immunology, vol.4, issue.2, pp.110-116, 2003.
DOI : 10.1038/ni0203-110

S. Yamasaki and T. Saito, Inhibitory adaptors in lymphocytes, Seminars in Immunology, vol.16, issue.6, pp.421-427, 2004.
DOI : 10.1016/j.smim.2004.08.021

V. Horejsi, W. Zhang, and B. Schraven, Transmembrane adaptor proteins: organizers of immunoreceptor signalling, Nature Reviews Immunology, vol.168, issue.8, pp.603-616, 2004.
DOI : 10.1091/mbc.E03-08-0574

L. E. Samelson, : The Role of Adapter Proteins, Annual Review of Immunology, vol.20, issue.1, pp.371-394, 2002.
DOI : 10.1146/annurev.immunol.20.092601.111357

S. Yamasaki, K. Nishida, M. Sakuma, D. Berry, C. J. Mcglade et al., Gads/Grb2-Mediated Association with LAT Is Critical for the Inhibitory Function of Gab2 in T Cells, Molecular and Cellular Biology, vol.23, issue.7, pp.2515-2529, 2003.
DOI : 10.1128/MCB.23.7.2515-2529.2003

O. Malbec, M. Malissen, I. Isnardi, R. Lesourne, A. M. Mura et al., Linker for Activation of T Cells Integrates Positive and Negative Signaling in Mast Cells, The Journal of Immunology, vol.173, issue.8, pp.5086-5094, 2004.
DOI : 10.4049/jimmunol.173.8.5086
URL : https://hal.archives-ouvertes.fr/pasteur-00271635

J. G. Nemorin, P. Laporte, G. Berube, and P. Duplay, p62dok Negatively Regulates CD2 Signaling in Jurkat Cells, The Journal of Immunology, vol.166, issue.7, pp.4408-4415, 2001.
DOI : 10.4049/jimmunol.166.7.4408

I. Boulay, J. G. Nemorin, and P. Duplay, Phosphotyrosine Binding-Mediated Oligomerization of Downstream of Tyrosine Kinase (Dok)-1 and Dok-2 Is Involved in CD2-Induced Dok Phosphorylation, The Journal of Immunology, vol.175, issue.7, pp.4483-4489, 2005.
DOI : 10.4049/jimmunol.175.7.4483

R. Shen, Y. B. Ouyang, C. K. Qu, A. Alonso, L. Sperzel et al., Grap Negatively Regulates T-Cell Receptor-Elicited Lymphocyte Proliferation and Interleukin-2 Induction, Molecular and Cellular Biology, vol.22, issue.10, pp.3230-3236, 2002.
DOI : 10.1128/MCB.22.10.3230-3236.2002

M. Zhu, O. Granillo, R. Wen, K. Yang, X. Dai et al., Negative Regulation of Lymphocyte Activation by the Adaptor Protein LAX, The Journal of Immunology, vol.174, issue.9, pp.5612-5619, 2005.
DOI : 10.4049/jimmunol.174.9.5612

N. Carpino, D. Wisniewski, A. Strife, D. Marshak, R. Kobayashi et al., (dok): a constitutively tyrosinephosphorylated , GAP-associated protein in chronic myelogenous leukemia progenitor cells, Cell, vol.88, pp.62197-204, 1997.

Y. Yamanashi and D. Baltimore, Identification of the Abl- and rasGAP-Associated 62 kDa Protein as a Docking Protein, Dok, Cell, vol.88, issue.2, pp.205-211, 1997.
DOI : 10.1016/S0092-8674(00)81841-3

D. Cristofano, A. , N. Carpino, N. Dunant, G. Friedland et al., Molecular Cloning and Characterization of p56dok-2 Defines a New Family of RasGAP-binding Proteins, Journal of Biological Chemistry, vol.273, issue.9, pp.4827-4830, 1998.
DOI : 10.1074/jbc.273.9.4827

N. Jones and D. J. Dumont, The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R, Oncogene, vol.17, issue.9, pp.1097-1108, 1998.
DOI : 10.1038/sj.onc.1202115

K. Nelms, A. L. Snow, J. Hu-li, and W. E. Paul, FRIP, a Hematopoietic Cell-Specific rasGAP-Interacting Protein Phosphorylated in Response to Cytokine Stimulation, Immunity, vol.9, issue.1, pp.13-24, 1998.
DOI : 10.1016/S1074-7613(00)80584-1

S. Lemay, D. Davidson, S. Latour, and A. Veillette, Dok-3, a Novel Adapter Molecule Involved in the Negative Regulation of Immunoreceptor Signaling, Molecular and Cellular Biology, vol.20, issue.8, pp.2743-2754, 2000.
DOI : 10.1128/MCB.20.8.2743-2754.2000

M. Niki, A. Di-cristofano, M. Zhao, H. Honda, H. Hirai et al., Role of Dok-1 and Dok-2 in Leukemia Suppression, The Journal of Experimental Medicine, vol.95, issue.12, pp.1689-1695, 2004.
DOI : 10.1038/sj.onc.1201005

T. Yasuda, M. Shirakata, A. Iwama, A. Ishii, Y. Ebihara et al., Role of Dok-1 and Dok-2 in Myeloid Homeostasis and Suppression of Leukemia, The Journal of Experimental Medicine, vol.95, issue.12, pp.1681-1687, 2004.
DOI : 10.1038/sj.onc.1206620

D. Cristofano, A. , M. Niki, M. Zhao, F. G. Karnell et al., dok), a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210(bcr-abl, J. Exp. Med, vol.194, pp.62275-284, 2001.

Y. Yamanashi, T. Tamura, T. Kanamori, H. Yamane, H. Nariuchi et al., Role of the rasGAP-associated docking protein p62(dok) in negative regulation of B cell receptormediated signaling, Genes Dev, vol.14, pp.11-16, 2000.

R. Gugasyan, C. Quilici, I. St, D. Grail, A. M. Verhagen et al., Dok-related protein negatively regulates T cell development via its RasGTPase-activating protein and Nck docking sites, The Journal of Cell Biology, vol.14, issue.1, pp.115-125, 2002.
DOI : 10.1016/S1074-7613(00)80032-1

D. Cai, S. Dhe-paganon, P. A. Melendez, J. Lee, and S. E. Shoelson, Two New Substrates in Insulin Signaling, IRS5/DOK4 and IRS6/DOK5, Journal of Biological Chemistry, vol.278, issue.28, pp.25323-25330, 2003.
DOI : 10.1074/jbc.M212430200

I. Tamir, J. C. Stolpa, C. D. Helgason, K. Nakamura, P. Bruhns et al., The RasGAP-Binding Protein p62dok Is a Mediator of Inhibitory Fc??RIIB Signals in B Cells, Immunity, vol.12, issue.3, pp.347-358, 2000.
DOI : 10.1016/S1074-7613(00)80187-9

M. J. Wick, L. Q. Dong, D. Hu, P. Langlais, and F. Liu, Insulin Receptor-mediated p62dok Tyrosine Phosphorylation at Residues 362 and 398 Plays Distinct Roles for Binding GTPase-activating Protein and Nck and Is Essential for Inhibiting Insulin-stimulated Activation of Ras and Akt, Journal of Biological Chemistry, vol.276, issue.46, pp.42843-42850, 2001.
DOI : 10.1074/jbc.M102116200

P. Van-slyke, M. L. Coll, Z. Master, H. Kim, J. Filmus et al., Dok-R Mediates Attenuation of Epidermal Growth Factor-Dependent Mitogen-Activated Protein Kinase and Akt Activation through Processive Recruitment of c-Src and Csk, Molecular and Cellular Biology, vol.25, issue.9, pp.3831-3841, 2005.
DOI : 10.1128/MCB.25.9.3831-3841.2005

M. P. Martelli, J. Boomer, M. Bu, and B. E. Bierer, T Cell Regulation of p62dok (Dok1) Association with Crk-L, Journal of Biological Chemistry, vol.276, issue.49, pp.45654-45661, 2001.
DOI : 10.1074/jbc.M105777200

. Acuto, CD28 as a molecular amplifi er extending TCR ligation and signaling capabilities, Immunity, vol.15, pp.935-945, 2001.

R. W. Freeburn, K. L. Wright, S. J. Burgess, E. Astoul, D. A. Cantrell et al., Evidence That SHIP-1 Contributes to Phosphatidylinositol 3,4,5-Trisphosphate Metabolism in T Lymphocytes and Can Regulate Novel Phosphoinositide 3-Kinase Effectors, The Journal of Immunology, vol.169, issue.10, pp.5441-5450, 2002.
DOI : 10.4049/jimmunol.169.10.5441

M. C. Seminario, P. Precht, S. C. Bunnell, S. E. Warren, C. M. Morris et al., PTEN permits acute increases in D3-phosphoinositide levels following TCR stimulation but inhibits distal signaling events by reducing the basal activity of Akt, European Journal of Immunology, vol.187, issue.11, pp.3165-3175, 2004.
DOI : 10.1002/eji.200425206

S. Latour, G. Gish, C. D. Helgason, R. K. Humphries, T. Pawson et al., Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product, Nature Immunology, vol.8, issue.8, pp.681-690, 2001.
DOI : 10.1038/90615

J. E. Damen, L. Liu, P. Rosten, R. K. Humphries, A. B. Jeff-erson et al., The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3, Proc. Natl. Acad. Sci. USA, pp.5-5, 1996.

T. S. Finco, T. Kadlecek, W. Zhang, L. E. Samelson, and A. Weiss, LAT Is Required for TCR-Mediated Activation of PLC??1 and the Ras Pathway, Immunity, vol.9, issue.5, pp.617-626, 1998.
DOI : 10.1016/S1074-7613(00)80659-7

W. Zhang, J. Sloan-lancaster, J. Kitchen, R. P. Trible, and L. E. Samelson, LAT, Cell, vol.92, issue.1, pp.83-92, 1998.
DOI : 10.1016/S0092-8674(00)80901-0
URL : https://hal.archives-ouvertes.fr/insu-01492674

J. Abramson, G. Rozenblum, and I. Pecht, Dok protein family members are involved in signaling mediated by the type 1 Fc?? receptor, European Journal of Immunology, vol.33, issue.1, pp.85-91, 2003.
DOI : 10.1002/immu.200390011

S. Horn, E. Endl, B. Fehse, M. M. Weck, G. W. Mayr et al., Restoration of SHIP activity in a human leukemia cell line downregulates constitutively activated phosphatidylinositol 3-kinase/Akt/GSK-3?? signaling and leads to an increased transit time through the G1 phase of the cell cycle, Leukemia, vol.18, issue.11, pp.1839-1849, 2004.
DOI : 10.1038/sj.leu.2403529

M. Zhu, E. Janssen, K. Leung, and W. Zhang, Molecular Cloning of a Novel Gene Encoding a Membrane-associated Adaptor Protein (LAX) in Lymphocyte Signaling, Journal of Biological Chemistry, vol.277, issue.48, pp.46151-46158, 2002.
DOI : 10.1074/jbc.M208946200

M. Zhao, J. A. Janas, M. Niki, P. P. Pandolfi, and L. Van-aelst, Dok-1 Independently Attenuates Ras/Mitogen-Activated Protein Kinase and Src/c-Myc Pathways To Inhibit Platelet-Derived Growth Factor-Induced Mitogenesis, Molecular and Cellular Biology, vol.26, issue.7, pp.2479-2489, 2006.
DOI : 10.1128/MCB.26.7.2479-2489.2006

J. D. Robson, D. Davidson, and A. Veillette, Inhibition of the Jun N-Terminal Protein Kinase Pathway by SHIP-1, a Lipid Phosphatase That Interacts with the Adaptor Molecule Dok-3, Molecular and Cellular Biology, vol.24, issue.6, pp.2332-2343, 2004.
DOI : 10.1128/MCB.24.6.2332-2343.2004

D. Bartolo, V. , D. Mege, V. Germain, M. Pelosi et al., Tyrosine 319, a Newly Identified Phosphorylation Site of ZAP-70, Plays a Critical Role in T Cell Antigen Receptor Signaling, Journal of Biological Chemistry, vol.274, issue.10, pp.6285-6294, 1999.
DOI : 10.1074/jbc.274.10.6285
URL : https://hal.archives-ouvertes.fr/hal-00138130

Q. Liu, T. Sasaki, I. Kozieradzki, A. Wakeham, A. Itie et al., SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival, Genes & Development, vol.13, issue.7, pp.786-791, 1999.
DOI : 10.1101/gad.13.7.786

L. P. Kane and A. Weiss, The PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3, Immunological Reviews, vol.114, issue.1, pp.7-20, 2003.
DOI : 10.1101/gad.13.22.2905

P. S. Costello, M. Gallagher, and D. A. Cantrell, Sustained and dynamic inositol lipid metabolism inside and outside the immunological synapse, Nature Immunology, vol.3, issue.11, pp.1082-1089, 2002.
DOI : 10.1038/ni848

J. P. Roose, M. Diehn, M. G. Tomlinson, J. Lin, A. A. Alizadeh et al., T Cell Receptor-Independent Basal Signaling via Erk and Abl Kinases Suppresses RAG Gene Expression, PLoS Biology, vol.275, issue.2, p.53, 2003.
DOI : 10.1371/journal.pbio.0000053.g007

Y. Hamel, P. Rohrlich, V. Baron, D. Bonhomme, F. Rieux-laucat et al., Characterization of antigen-specific repertoire diversity following in vitro restimulation by a recombinant adenovirus expressing human cytomegalovirus pp65, European Journal of Immunology, vol.33, issue.3, pp.760-768, 2003.
DOI : 10.1002/eji.200323628

C. Irles, A. Symons, F. Michel, T. R. Bakker, P. A. Van-der-merwe et al., CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling, Nature Immunology, vol.4, issue.2, pp.189-197, 2003.
DOI : 10.1038/ni877