Indexation as a novel mechanism of lymphocyte homeostasis: the number of CD4+CD25+ regulatory T cells is indexed to the number of IL-2-producing cells. - Archive ouverte HAL Access content directly
Journal Articles Journal of Immunology Year : 2006

Indexation as a novel mechanism of lymphocyte homeostasis: the number of CD4+CD25+ regulatory T cells is indexed to the number of IL-2-producing cells.

Abstract

To fulfill its mission, the immune system must maintain a complete set of different cellular subpopulations that play specific roles in immune responses. We have investigated the mechanisms regulating CD4+CD25+ regulatory T (Treg) cell homeostasis. We show that the expression of the high-affinity IL-2Ralpha endows these cells with the capacity to explore the IL-2 resource, ensuring their presence while keeping their number tied to the number of CD4+ T cells that produce IL-2. We show that such a homeostatic mechanism allows the increased expansion of T cells without causing disease. The indexing of Treg cells to the number of activated IL-2-producing cells may constitute a feedback mechanism that controls T cell expansion during immune responses, thus preventing autoimmune or lymphoproliferative diseases. The present study highlights that maintenance of proportions between different lymphocyte subsets may also be critical for the immune system and are under strict homeostatic control.

Dates and versions

pasteur-00161683 , version 1 (31-07-2007)

Identifiers

Cite

Afonso R M Almeida, Bruno Zaragoza, Antonio A Freitas. Indexation as a novel mechanism of lymphocyte homeostasis: the number of CD4+CD25+ regulatory T cells is indexed to the number of IL-2-producing cells.. Journal of Immunology, 2006, 177 (1), pp.192-200. ⟨10.4049/jimmunol.177.1.192⟩. ⟨pasteur-00161683⟩
53 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More