S. Sakaguchi, Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self, Nature Immunology, vol.168, issue.4, pp.345-352, 2005.
DOI : 10.1016/1074-7613(95)90125-6

H. Von-boehmer, Mechanisms of suppression by suppressor T cells, Nature Immunology, vol.59, issue.4, pp.338-344, 2005.
DOI : 10.1038/ni1059

J. L. Coombes, N. J. Robinson, K. J. Maloy, H. H. Uhlig, and F. Powrie, Regulatory T cells and intestinal homeostasis, Immunological Reviews, vol.173, issue.1, pp.184-194, 2005.
DOI : 10.1084/jem.186.7.1099

O. Taguchi and T. Takahashi, Administration of anti-interleukin-2 receptor ?? antibodyin vivo induces localized autoimmune disease, European Journal of Immunology, vol.268, issue.7, pp.1608-1612, 1996.
DOI : 10.1002/eji.1830260730

R. S. Mchugh and E. M. Shevach, Cutting Edge: Depletion of CD4+CD25+ Regulatory T Cells Is Necessary, But Not Sufficient, for Induction of Organ-Specific Autoimmune Disease, The Journal of Immunology, vol.168, issue.12, pp.5979-5983, 2002.
DOI : 10.4049/jimmunol.168.12.5979

F. Leithauser, T. Meinhardt-krajina, K. Fink, B. Wotschke, P. Moller et al., Foxp3-Expressing CD103+ Regulatory T Cells Accumulate in Dendritic Cell Aggregates of the Colonic Mucosa in Murine Transfer Colitis, The American Journal of Pathology, vol.168, issue.6, pp.1898-1909, 2006.
DOI : 10.2353/ajpath.2006.050228

D. J. Needham, J. X. Lee, and M. W. Beilharz, Intra-tumoural regulatory T cells: A potential new target in cancer immunotherapy, Biochemical and Biophysical Research Communications, vol.343, issue.3, pp.684-691, 2006.
DOI : 10.1016/j.bbrc.2006.03.018

S. Onizuka, I. Tawara, J. Shimizu, S. Sakaguchi, T. Fujita et al., Tumor rejection by in vivo administration of anti- CD25 (interleukin-2 receptor alpha) monoclonal antibody, Cancer Res, vol.59, pp.3128-3133, 1999.

R. P. Sutmuller, L. M. Van-duivenvoorde, A. Van-elsas, T. N. Schumacher, M. E. Wildenberg et al., Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses, The Journal of Experimental Medicine, vol.60, issue.6, pp.823-832, 2001.
DOI : 10.1084/jem.190.5.705

J. D. Fontenot and A. Y. Rudensky, A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3, Nature Immunology, vol.14, issue.4, pp.331-337, 2005.
DOI : 10.1093/intimm/dxh165

J. D. Fontenot, M. A. Gavin, and A. Y. Rudensky, Foxp3 programs the development and function of CD4+CD25+ regulatory T cells, Nature Immunology, vol.4, issue.4, pp.330-336, 2003.
DOI : 10.1038/ni904

S. Hori, T. Nomura, and S. Sakaguchi, Control of Regulatory T Cell Development by the Transcription Factor Foxp3, Science, vol.299, issue.5609, pp.1057-1061, 2003.
DOI : 10.1126/science.1079490

M. E. Brunkow, E. W. Jeff-ery, K. A. Hjerrild, B. Paeper, L. B. Clark et al., Disruption of a new forkhead/winged-helix protein, scurfi n, results in the fatal lymphoproliferative disorder of the scurfy mouse, Nature Genetics, vol.27, issue.1, pp.68-73, 2001.
DOI : 10.1038/83784

V. L. Godfrey, J. E. Wilkinson, E. M. Rinchik, and L. B. Russell, Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in a sf thymic environment: potential model for thymic education., Proc. Natl. Acad. Sci. USA, pp.5528-5532, 1991.
DOI : 10.1073/pnas.88.13.5528

X. Chang, J. X. Gao, Q. Jiang, J. Wen, N. Seifers et al., in the thymus stroma leads to defective thymopoiesis, The Journal of Experimental Medicine, vol.138, issue.8, pp.1141-1151, 2005.
DOI : 10.1016/S1074-7613(01)00180-7

P. J. Blair, S. J. Bultman, J. C. Haas, B. T. Rouse, J. E. Wilkinson et al., CD4+CD8? T cells are the eff ector cells in disease pathogenesis in the scurfy (sf) mouse, J. Immunol, vol.153, pp.3764-3774, 1994.

M. S. Jordan, A. Boesteanu, A. J. Reed, A. L. Petrone, A. E. Holenbeck et al., Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide, Nature Immunology, vol.180, issue.4, pp.301-306, 2001.
DOI : 10.1038/86302

C. S. Hsieh, Y. Liang, A. J. Tyznik, S. G. Self, D. Liggitt et al., Recognition of the Peripheral Self by Naturally Arising CD25+ CD4+ T Cell Receptors, Immunity, vol.21, issue.2, pp.267-277, 2004.
DOI : 10.1016/j.immuni.2004.07.009

C. S. Hsieh, Y. Zheng, Y. Liang, J. D. Fontenot, and A. Y. Rudensky, An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires, Nature Immunology, vol.164, issue.4, pp.401-410, 2006.
DOI : 10.1038/ni1318

J. D. Fontenot, J. P. Rasmussen, L. M. Williams, J. L. Dooley, A. G. Farr et al., Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3, Immunity, vol.22, issue.3, pp.329-341, 2005.
DOI : 10.1016/j.immuni.2005.01.016

Y. Y. Wan and R. A. , Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter, Proc. Natl. Acad. Sci. USA, pp.5126-5131, 2005.
DOI : 10.1073/pnas.0501701102

R. Peff-ault-de-latour, H. C. Dujardin, F. Mishellany, O. Burlen-defranoux, J. Zuber et al., Ontogeny, function, and peripheral homeostasis of regulatory T cells in the absence of interleukin-7, Blood, vol.108, issue.7, pp.2300-2306, 2006.
DOI : 10.1182/blood-2006-04-017947

V. L. Godfrey, J. E. Wilkinson, and L. B. Russell, X-linked lymphoreticular disease in the scurfy (sf) mutant mouse, Am. J. Pathol, vol.138, pp.1379-1387, 1991.

X. W. Yang, P. Model, and N. Heintz, Homologous recombination based modification in Esherichia coli and germline transmission in transgenic mice of a bacterial artificial chromsome, Nature Biotechnology, vol.12, issue.9, pp.859-865, 1997.
DOI : 10.1038/nbt0997-859

T. Sparwasser, S. Gong, J. Y. Li, and G. Eberl, General method for the modification of different BAC types and the rapid generation of BAC transgenic mice, genesis, vol.97, issue.1, pp.39-50, 2004.
DOI : 10.1002/gene.10249

URL : https://hal.archives-ouvertes.fr/pasteur-01402770

S. Jung, D. Unutmaz, P. Wong, G. Sano, K. De-los-santos et al., In Vivo Depletion of CD11c+ Dendritic Cells Abrogates Priming of CD8+ T Cells by Exogenous Cell-Associated Antigens, vivo depletion of CD11c(+) dendritic cells abrogates priming of CD8(+) T cells by exogenous cell-associated antigens, pp.211-220, 2002.
DOI : 10.1016/S1074-7613(02)00365-5

G. Eberl and D. R. Littman, Thymic Origin of Intestinal ???? T Cells Revealed by Fate Mapping of ROR??t+ Cells, Science, vol.305, issue.5681, pp.248-251, 2004.
DOI : 10.1126/science.1096472

C. Loddenkemper, J. Maul, E. Berg, H. Stein, M. Zeitz et al., To the Editor - Eur. J. Immunol. 1/2006, European Journal of Immunology, vol.128, issue.1, p.245, 2006.
DOI : 10.1002/eji.200535651

M. E. Sunday, J. Z. Weinberger, B. Benacerraf, and M. E. Dorf, Hapten-specifi c T cell responses to 4-hydroxy-3-nitrophenyl acetyl, J. Immunol, vol.125, pp.1601-1605, 1980.