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Inducible lymphoid tissues in the adult gut: recapitulation of a fetal developmental pathway?

Gérard Eberl 1, *
Abstract : The intestinal immune system faces an extraordinary challenge from the large numbers of commensal bacteria and potential pathogens that are restrained by only a single layer of epithelial cells. Here, I discuss evidence that the intestinal immune system develops an extensive network of inducible, reversible lymphoid tissues that contributes to the vital equilibrium between the gut and the bacterial flora. I propose that this network is induced by cryptopatches, which are small clusters of dendritic cells and lymphoid cells that are identical to fetal inducers of lymph-node and Peyer's-patch development.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-00161185
Contributor : Bérengère Hugot <>
Submitted on : Tuesday, July 10, 2007 - 10:13:15 AM
Last modification on : Monday, January 13, 2020 - 5:08:07 PM

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Gérard Eberl. Inducible lymphoid tissues in the adult gut: recapitulation of a fetal developmental pathway?. Nature Reviews Immunology, Nature Publishing Group, 2005, 5, pp.413-420. ⟨10.1038/nri1600⟩. ⟨pasteur-00161185⟩

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