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Adult neurogenesis and functional plasticity in neuronal circuits.

Abstract : The adult brain is a plastic place. To ensure that the mature nervous system's control of behaviour is flexible in the face of a varying environment, morphological and physiological changes are possible at many levels, including that of the entire cell. In two areas of the adult brain - the olfactory bulb and the dentate gyrus - new neurons are generated throughout life and form an integral part of the normal functional circuitry. This process is not fixed, but highly modulated, revealing a plastic mechanism by which the brain's performance can be optimized for a given environment. The functional benefits of this whole-cell plasticity, however, remain a matter for debate.
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Submitted on : Monday, July 9, 2007 - 12:06:40 PM
Last modification on : Monday, January 13, 2020 - 5:08:10 PM

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Pierre-Marie Lledo, Mariana Alonso, Matthew S. Grubb. Adult neurogenesis and functional plasticity in neuronal circuits.. Nature Reviews Neuroscience, Nature Publishing Group, 2006, 7 (3), pp.179-93. ⟨10.1038/nrn1867⟩. ⟨pasteur-00160881⟩

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