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Reduced apoptosis in human intestinal cells cured of persistent poliovirus infection.

Abstract : Cells cured of persistent virus infection can be used to investigate cellular pathways of resistance to viral cytopathic effects. Persistent poliovirus (PV) infections were established in human intestinal Caco-2 cells, and spontaneously cured cell cultures were obtained. Two cell clones, cl6 and b13, cured of type 3 PV mutant infection and their parental Caco-2 cells were compared for susceptibility to PV infection, PV receptor CD155 expression, capacity to differentiate into polarized enterocytes, and PV-, staurosporine-, and actinomycin D-induced apoptosis. Our results strongly suggest that cells that are partially resistant to apoptosis can be selected during persistent virus infection.
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Karine Labadie, Aure Saulnier, Sandra Martin-Latil, Florence Colbère-Garapin. Reduced apoptosis in human intestinal cells cured of persistent poliovirus infection.. Journal of Virology, American Society for Microbiology, 2007, 81 (6), pp.3033-6. ⟨10.1128/JVI.01960-06⟩. ⟨pasteur-00146511⟩

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