Skip to Main content Skip to Navigation
Journal articles

Homeostasis of T cell numbers: from thymus production to peripheral compartmentalization and the indexation of regulatory T cells.

Abstract : A system under homeostatic control tends to maintain its structure and functions by establishing dynamic equilibriums controlled by multiple regulatory mechanisms. We have shown that this is the case for immune system. Several different mechanisms seem to participate in the homeostatic control of T cell numbers and population distribution. In other words, besides a quantitative dimension, there is also a qualitative dimension in T cell homeostasis. This is achieved through competition by driving the specialization of sub-populations of lymphocytes to occupy specific niches in the peripheral pool and by developing independent homeostatic mechanisms for each particular cell sub-set. Thus, the sizes of the na? and memory T cell compartments are governed by independent homeostatic mechanisms, which preserve the capacity to deal with any novel infection (conferred by the presence of na? T cells) whilst ensuring the efficacy of memory responses when dealing with recurring antigens. Peripheral T cell homeostasis also depends on the integrity of sub-population structure and the presence of regulatory CD4+ CD25+ T cells. The indexation of regulatory CD4+ CD25+ T cell numbers to the numbers of peripheral activated CD4+ T cells is another mechanism of homeostasis that has major advantages in the control of immune responses. It ensures continuous regulation of T cell numbers throughout immune responses, allowing for increases in cell numbers as long as the proportion of CD4+ CD25+ regulatory T cells is kept.
Document type :
Journal articles
Complete list of metadatas

Cited literature [91 references]  Display  Hide  Download

https://hal-pasteur.archives-ouvertes.fr/pasteur-00019660
Contributor : Marie-Christine Vougny <>
Submitted on : Tuesday, July 31, 2007 - 3:16:18 PM
Last modification on : Friday, March 27, 2020 - 2:23:36 AM
Long-term archiving on: : Friday, November 25, 2016 - 10:10:13 AM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Citation

Afonso R M Almeida, Benedita Rocha, Antonio A Freitas, Corine Tanchot. Homeostasis of T cell numbers: from thymus production to peripheral compartmentalization and the indexation of regulatory T cells.. Seminars in Immunology, Elsevier, 2007, 17 (3), pp.239-49. ⟨10.1016/j.smim.2005.02.002⟩. ⟨pasteur-00019660⟩

Share

Metrics

Record views

346