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Extensive editing of a small fraction of human T-cell leukemia virus type 1 genomes by four APOBEC3 cytidine deaminases.

Abstract : In the absence of the human immunodeficiency virus type 1 (HIV-1) Vif protein, the host-cell cytidine deaminases APOBEC3F and -3G are co-packaged along with virion RNA. Upon infection of target cells, nascent single-stranded DNA can be edited extensively, invariably giving rise to defective genomes called G-->A hypermutants. Although human T-cell leukemia virus type 1 (HTLV-1) replicates in the same cell type as HIV-1, it was shown here that HTLV-1 is relatively resistant to the antiviral effects mediated by human APOBEC3B, -3C, -3F and -3G. Nonetheless, a small percentage of genomes (0.1
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https://hal-pasteur.archives-ouvertes.fr/pasteur-00013751
Contributor : Mireille Gau <>
Submitted on : Thursday, November 10, 2005 - 2:30:37 PM
Last modification on : Friday, April 10, 2020 - 5:11:37 PM

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Renaud Mahieux, Rodolphe Suspene, Frédéric Delebecque, Michel Henry, Olivier Schwartz, et al.. Extensive editing of a small fraction of human T-cell leukemia virus type 1 genomes by four APOBEC3 cytidine deaminases.. Journal of General Virology, Microbiology Society, 2005, 86 (Pt 9), pp.2489-94. ⟨10.1099/vir.0.80973-0⟩. ⟨pasteur-00013751⟩

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