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La recherche de ganglion sentinelle a-t-elle des indications dans les cancers digestifs ?

Matthieu Faron 1, 2, 3, * Enora Laas 4 
Abstract : Despite being a standard of care in several cancers, sentinel lymph node (SLN) is not widespread in digestive cancers. European guidelines do not recommend its use for any digestive cancers. Particularity of the lymphatic vessel, intimately linked to blood vessel, may explain part of this phenomenon. Nevertheless, more indication could arise in the near future with the early diagnosis of tumor induced by cancer screening. Ruling out the lymphatic invasion could allow preserving the organ currently resected because of risk of lymph node positivity. This procedure is well studied in early gastric cancer in Korea and Japan. Several study have demonstrated that, a dual-tracer (isotopic and dye) allows to accurately identify the SLN. A randomized phase 3 trial is currently active in Korea to evaluate the oncological results of the procedure. Similar indication could arise for T1 tumor of the low-rectum, but currently available data are insufficient to recommend its use outside of a study. SLN may also be used to detect aberrant lymphatic drainage (rectum, ileum) but have been tested so far only in a few dozen of patients. Finally, SLN is disappointing in colon cancer, due to its low sensitivity and the absence of modification of the surgical procedure induced.
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Submitted on : Thursday, June 16, 2022 - 8:02:29 AM
Last modification on : Friday, June 24, 2022 - 4:49:51 PM

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Matthieu Faron, Enora Laas. La recherche de ganglion sentinelle a-t-elle des indications dans les cancers digestifs ?. Bulletin du Cancer, John Libbey Eurotext, 2020, 107, pp.660 - 665. ⟨10.1016/j.bulcan.2019.06.013⟩. ⟨hal-03490189⟩

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