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Article Dans Une Revue Cytokine and Growth Factor Reviews Année : 2020

Cytokines in oncolytic virotherapy

Résumé

Tumors represent a hostile environment for the effector cells of cancer immunosurveillance. Immunosuppressive receptors and soluble or membrane-bound ligands are abundantly exposed and released by malignant entities and their stromal accomplices. As a consequence, executioners of antitumor immunity inefficiently navigate across cancer tissues and fail to eliminate malignant targets. By inducing immunogenic cancer cell death, oncolytic viruses profoundly reshape the tumor microenvironment. They trigger the local spread of danger signals and tumor-associated (as well as viral) antigens, thus attracting antigen-presenting cells, promoting the activation and expansion of lymphocytic populations, facilitating their infiltration in the tumor bed, and reinvigorating cytotoxic immune activity. The present review recapitulates key chemokines, growth factors and other cytokines that orchestrate this ballet of antitumoral leukocytes upon oncolytic virotherapy.
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Origine : Publication financée par une institution

Dates et versions

hal-03354194 , version 1 (24-09-2021)

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Jonathan Pol, Samuel T Workenhe, Prathyusha Konda, Shashi Gujar, Guido Kroemer. Cytokines in oncolytic virotherapy. Cytokine and Growth Factor Reviews, 2020, 56, pp.4-27. ⟨10.1016/j.cytogfr.2020.10.007⟩. ⟨hal-03354194⟩
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