PMID: identifiant
de la référence Pubmed : |
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 (20005786) |
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| titre : |
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Cystic fibrosis transmembrane conductance regulator (CFTR) regulates the production of osteoprotegerin (OPG) and prostaglandin (PG) E2 in human bone. |
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| auteur(s) : |
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Louis Le Heron1, Christine Guillaume1, Frédéric Velard1, Julien Braux1, Lhousseine Touqui2, Sandra Moriceau3, Isabelle Sermet-Gaudelus3, Dominique Laurent-Maquin1, Jacky Jacquot ( ) 1 |
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| laboratoire : |
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| résumé : |
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Bone loss is an important clinical issue in patients with cystic fibrosis (CF). Whether the cystic fibrosis transmembrane conductance regulator (CFTR) plays a direct role in bone cell function is yet unknown. In this study, we provide evidence that inhibition of CFTR-Cl(-) channel function results in a significant decrease of osteoprotegerin (OPG) secretion accompanied with a concomitant increase of prostaglandin (PG) E(2) secretion of primary human osteoblast cultures (n=5). Our data therefore suggest that in bone cells of CF patients, the loss of CFTR activity may result in an increased inflammation-driven bone resorption (through both the reduced OPG and increased PGE(2) production), and thus might contribute to the early bone loss reported in young children with CF. |
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| domaine : |
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langue du texte
intégral : |
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Anglais |
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| ISSN : |
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1873-5010 |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| DOI : |
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10.1016/j.jcf.2009.11.005 |
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| journal : |
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| Journal of Cystic Fibrosis (J Cyst Fibros) |
| Publisher |
Elsevier |
| ISSN |
1569-1993 |
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| Audience : |
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internationale |
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| date de publication : |
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01/2010 |
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date de publication
électronique : |
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14/12/2009 |
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| volume : |
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9 |
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| numéro : |
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1 |
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| page, identifiant, ... : |
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69-72 |
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| mots-clés auteur : |
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CFTR – human bone – OPG – PGE2 – osteoclatogenesis |
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| Descripteur(s) MeSH : |
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Aged – Bone Resorption – Cells – Cultured – Cystic Fibrosis – Cystic Fibrosis Transmembrane Conductance Regulator – Dinoprostone – Female – Humans – Middle Aged – Osteoblasts – Osteoprotegerin – RNA – Messenger – Reverse Transcriptase Polymerase Chain Reaction |
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