| Domaine : |
 |
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PMID (identifiant
de la référence Pubmed) : |
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 (20195256) |
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| Titre : |
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Visualization of macromolecular structures. |
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| Auteur(s) : |
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Seán I O'Donoghue ( ) 1, David S Goodsell2, Achilleas S Frangakis3, Fabrice Jossinet () 4, Roman A Laskowski5, Michael Nilges6, Helen R Saibil7, Andrea Schafferhans1, Rebecca C Wade8, Eric Westhof () 4, Arthur J Olson2 |
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| Laboratoire : |
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| 1 : |
EMBL - European Molecular Biology Laboratory |
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| http://www.embl.de/ |
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| European Molecular Biology Laboratory |
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| Meyerhofstraße 1, 69117 Heidelberg, Germany |
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| Allemagne |
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| 2 : |
The Scripps Research Institute |
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| The Scripps Research Institute |
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| La Jolla, USA |
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| États-Unis |
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| 3 : |
Goethe University, Frankfurt |
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| Goethe University, Frankfurt |
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| Goethe University Frankfurt Germany |
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| Allemagne |
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| 4 : |
ARN - Architecture et réactivité de l'ARN |
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| http://www-ibmc.u-strasbg.fr/arn/ |
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| CNRS : UPR9002 – Université de Strasbourg |
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| Institut de Biologie Moléculaire et Cellulaire 15 rue René Descartes 67084 STRASBOURG Cedex |
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| France |
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| 5 : |
European Bioinformatics Institute, Cambridge |
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| European Bioinformatics Institute, Cambridge |
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| European Bioinformatics institute Cambridge UK |
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| Royaume-Uni |
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| 6 : |
Bioinformatique Structurale |
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| CNRS : URA2185 – Institut Pasteur de Paris |
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| 25-28 rue du Dr Roux F-75724 Paris CEDEX 15 |
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| France |
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| 7 : |
Institute of Structural and Molecular Biology, Birkbeck College |
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| Institute of Structural and Molecular Biology, Birkbeck College |
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| Institute of Structural and Molecular Biology Birkbeck College London UK |
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| Royaume-Uni |
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| 8 : |
Heidelberg Institute for Theoretical Sciences (HITS), Heidelberg |
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| Heidelberg Institute for Theoretical Sciences (HITS), Heidelberg |
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| Heidelberg Institute for Theoretical Sciences (HITS) Heidelberg Germany |
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| Allemagne |
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| Résumé : |
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Structural biology is rapidly accumulating a wealth of detailed information about protein function, binding sites, RNA, large assemblies and molecular motions. These data are increasingly of interest to a broader community of life scientists, not just structural experts. Visualization is a primary means for accessing and using these data, yet visualization is also a stumbling block that prevents many life scientists from benefiting from three-dimensional structural data. In this review, we focus on key biological questions where visualizing three-dimensional structures can provide insight and describe available methods and tools. |
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Langue du texte
intégral : |
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Anglais |
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| Type de publication : |
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Articles dans des revues avec comité de lecture |
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| DOI : |
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10.1038/nmeth.1427 |
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| Journal : |
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| Nature Methods |
| Publisher |
Nature Publishing Group |
| ISSN |
1548-7091 (eISSN : 1548-7105) |
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| Audience : |
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internationale |
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| Date de publication : |
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03/2010 |
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Date de publication
électronique : |
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01/03/2010 |
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| Volume : |
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7 |
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| Numéro : |
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3 Suppl |
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| Page, identifiant, ... : |
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S42-55 |
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| Descripteur(s) MeSH : |
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Crystallography – X-Ray – Image Processing – Computer-Assisted – Internet – Macromolecular Substances – Models – Molecular – Molecular Conformation |
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