The niche reduction approach: an opportunity for optimal control of infectious diseases in low-income countries?

Benjamin Roche (1) , Hélène Broutin (2) , Marc Choisy (2, 3) , Sylvain Godreuil (4) , Guillaume Constantin de Magny (5) , Yann Chevaleyre (6) , Jean-Daniel Zucker (1) , Romulus Breban (7) , Bernard Cazelles (1, 8) , Frédéric Simard (9)

1 UMMISCO - Unité de modélisation mathématique et informatique des systèmes complexes [Bondy]
2 MIVEGEC - Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle
3 OUCRU - Oxford University Clinical Research Unit [Ho Chi Minh City]
4 Pathogénèse et contrôle des infections chroniques (PCCI)
5 MIVEGEC-GeneSys - Du gène à l'écosystème
6 LIPN - Laboratoire d'Informatique de Paris-Nord
7 Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology
8 Laboratoire Ecologie et évolution
9 MIVEGEC-DEEVA - Diversity, ecology, evolution & Adaptation of arthropod vectors

BACKGROUND: During the last century, WHO led public health interventions that resulted in spectacular achievements such as the worldwide eradication of smallpox and the elimination of malaria from the Western world. However, besides major successes achieved worldwide in infectious diseases control, most elimination/control programs remain frustrating in many tropical countries where specific biological and socio-economical features prevented implementation of disease control over broad spatial and temporal scales. Emblematic examples include malaria, yellow fever, measles and HIV. There is consequently an urgent need to develop affordable and sustainable disease control strategies that can target the core of infectious diseases transmission in highly endemic areas. DISCUSSION: Meanwhile, although most pathogens appear so difficult to eradicate, it is surprising to realize that human activities are major drivers of the current high rate of extinction among upper organisms through alteration of their ecology and evolution, i.e., their "niche". During the last decades, the accumulation of ecological and evolutionary studies focused on infectious diseases has shown that the niche of a pathogen holds more dimensions than just the immune system targeted by vaccination and treatment. Indeed, it is situated at various intra- and inter- host levels involved on very different spatial and temporal scales. After developing a precise definition of the niche of a pathogen, we detail how major advances in the field of ecology and evolutionary biology of infectious diseases can enlighten the planning and implementation of infectious diseases control in tropical countries with challenging economic constraints. SUMMARY: We develop how the approach could translate into applied cases, explore its expected benefits and constraints, and we conclude on the necessity of such approach for pathogen control in low-income countries.

Domaines: Santé publique et épidémiologie

Benjamin Roche, Hélène Broutin, Marc Choisy, Sylvain Godreuil, Guillaume Constantin de Magny, et al.. The niche reduction approach: an opportunity for optimal control of infectious diseases in low-income countries?. BMC Public Health, 2014, 14 (1), pp.753. ⟨10.1186/1471-2458-14-753⟩. ⟨pasteur-01053863⟩