Transfer of small resting B cells into immunodeficient hosts results in the selection of a self-renewing activated B cell population.

Fabien Agenès (1) , António A. Freitas Freitas (1)

1 Dynamiques Lymphocytaires

We studied the role of bone marrow B cell production in the renewal of peripheral B cells and the feedback mechanisms that control the entry of newly formed B cells into the peripheral B cell pools. When resting lymph node B cells are injected into B cell-deficient hosts, a fraction of the transferred cells expands and constitutes a highly selected population that survives for prolonged periods of time by continuous cell renewal at the periphery. Although the number of donor B cells recovered is low, a significant fraction shows an activated phenotype, and the serum immunoglobulin (Ig)M levels are as in normal mice. This population of activated B cells is resistant to replacement by a new cohort of B cells and is able to feedback regulate both the entry of newly formed B cells into the peripheral pool and terminal differentiation. These findings suggest that peripheral B cell selection follows the first come, first served rule and that IgM-secreting cells are generated from a pool of stable activated B cells with an independent homeostasis.

Domaines: Immunologie

Fabien Agenès, António A. Freitas Freitas. Transfer of small resting B cells into immunodeficient hosts results in the selection of a self-renewing activated B cell population.. Journal of Experimental Medicine, 1999, 189 (2), pp.319-30. ⟨10.1084/jem.189.2.319⟩. ⟨pasteur-00327527⟩